Abstract： The state-target syndrome differentiation and treatment method is a clinical method in traditional Chinese medi-cine(TCM)created by Academician TONG Xiaolin.It integrates the research of modern science on diseases,and applies the re-search results of TCM pharmacology to the syndrome differentiation and treatment of diseases,further refinement of staging,syn-drome differentiation and clinical medication,integration of TCM and Western medicine,and improve the precision and standardi-zation of medicine use based on syndrome differentiation.According to"state-target syndrome differentiation and treatment",this article summarized the general state of depression as"depression",and the partial states of different courses of depression includ-ed"blood stasis","dampness","phlegm","fire"and"deficiency".It summarized and determined the formula for regulating state and target,and the target medicine for regulating biological targets such as HPA axis and 5-HT system,which can promote the"syndrome differentiation microscopization"and"precision medicine"of depression.