Abstract： Objective To explore the value of D-dimer(D-D),fibrinogen(Fib)and progesterone(P)in predicting the out-come of foetus preservation in early pregnancy with preeclampsia.Methods 200 cases of pregnant women with preterm miscarriage ad-mitted to the hospital from January 2022 to September 2023 were selected to receive fertility preservation treatment,and laboratory indi-cators were examined before fertility preservation treatment,and the outcomes of the pregnant women were followed up,and the patients were classified into the failure group and the success group according to the results,and the baseline data and laboratory indicators of the patients in the failure group and the success group were compared to each other,with emphasis on the analysis of the value of D-D,Fib,and P in predicting the outcome of preterm miscarriage in the early stages of pregnancy.Fib,P predicted the value of foetal preser-vation outcome.Results Statistically,62 cases with preeclamptic miscarriage failed to preserve the pregnancy,accounting for 31.00%(62/200).The levels of D-D and Fib in the failure group were higher than those in the success group,the level of P was lower than that in the success group with statistical differences(P<0.05),and there was no significant difference in the comparison of the other data between the groups(P>0.05).Regression analysis revealed that the overexpression of D-D and Fib were risk factors for the outcome of early pregnancy preeclampsia with foetal preservation(OR>1,P<0.05),and P overexpression was a protective factor for the outcome of early pregnancy preeclampsia with foetal preservation(OR<1,P<0.05);ROC curves were plotted,and the AUCs of D-D,Fib,and P for predicting the failure of foetal preservation for early pregnancy preeclampsia were all>0.70,which had an ideal predictive value.Conclu-sion D-D,Fib and P have ideal predictive value in predicting the failure of foetal preservation in early pregnancy with preeclampsia.With the increase of D-D and Fib level and the decrease of P level,the risk of failure of foetal preservation in pregnant women with pre-eclampsia in early pregnancy is increased.