Abstract： Objective To explore the independent risk factors for frailty in hospitalized elderly patients with cerebral infarction,and to construct a joint prediction model.Methods From March to November 2022,110 hospitalized elderly patients with cerebral in-farction in the Department of Neurology of a tertiary hospital were selected.The Basic Information Questionnaire,the Simple Frailty Screening Scale,the Brief Geriatric Depression Inventory and the Anxiety Self-assessment Scale were used to analyze 82 patients with pre frailty and 28 patients with frailty status.Results Univariate analysis combined with binary logistic multifactor regression showed that anxiety was an independent risk factor on frailty in hospitalized elderly patients with cerebral infarction(B=1.295,OR=3.650,P<0.05),and age was an independent risk factor on frailty in hospitalized elderly patients with cerebral infarction(B=0.128,OR=1.137,P<0.05);and the combined predictive model showed that the area under the ROC curve for the joint predictor was 0.825 with sensitivi-ty=0.679,specificity=0.866.Conclusion Anxiety and age are independent risk factors for frailty in hospitalized elderly patients with cerebral infarction and a joint prediction model was constructed with high accuracy.