Abstract： Objective To explore the risk factors of postoperative complications in patients undergoing radical gastrectomy for gastric cancer.Methods The data of 327 gastric cancer patients who underwent radical gastrectomy from January 2016 to January 2021 were retrospectively analyzed.According to their postoperative complications,they were divided into two groups,a postoperative complication group(n=143)and a non-postoperative complication group(n=184).The data were recorded and compared between the two groups.The risk factors of postoperative complications were identified by multivariate logistic regression analysis.Results Among the 327 patients,143 patients(43.7％)developed overall postoperative complications,117 patients(35.7％)developed severe postoperative complications(Clavien-Dindo grade ≥ Ⅱ),2 patients(0.6％)died.The intraoperative crystalloid volume(P=0.002)is an independent risk factor for overall postoperative complications.Compared with crystalloid volume≤ 1500 mL,intraoperative crystalloid volume＞2100 mL(OR=2.447,P=0.003)was more likely to develop overall postoperative complications.Postoperative complications were more likely reduced when patients received preoperative oral carbohydrate treatment(OR=0.5999,P=0.031).Conclusion Intraoperative crystalloid volume＞2100 mL is an independent risk factor for overall postoperative complications after radical gastrectomy for gastric cancer.