Abstract： For patients receiving in vitro fertilization-embryo transfer(IVF-ET)treatment,the pain and anxiety during transvaginal ultrasound-guided oocyte retrieval(TVUOR)are very serious and affect pregnancy outcomes.The analgesic methods had undergone early intervention by non-anesthesiologists and current routine anesthesiologists to achieve completely painless general anesthesia.It is a gradual process from intramuscular injection of analgesics,inhalation of N20,insertion of painkillers into the anus,acupuncture analgesia,intravenous low-dose midazolam/dexmedetomidine/fentanyl combination for conscious sedative and analgesic anesthesia,to now total intravenous anesthesia with propofol as the main component and narcotic analgesics(opioids)as auxiliary.The anesthesia methods and effects of commonly used opioid drugs combined with propofol in clinical practice were cited and introduced,as well as their impact on pregnancy outcomes.Propofol in follicular fluid may have adverse effects on oocytes quality.Improving anesthesia technique to reduce propofol consumption and shorten surgical time to avoid prolonged use of propofol is an effort to be made.At present,fentanyl series or κreceptor agonists may be more suitable for assisting propofol intravenous general anesthesia in TVUOR.