You Position: Home > Paper
Comparison of inhaling budesonide compound and budesonide only in treatment of asthma
( views:120, downloads:0 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF NANJING MILITARY MEDICAL COLLEGE
- Issue:
- 4
- DOI:
- No doi available
- Key Word:
- 哮喘;布地奈德;沙丁胺醇;溴化异丙托品
Abstract： 目的:比较联合吸入布地奈德加沙丁胺醇及溴化异丙托品与单纯吸入布地奈德治疗轻中度哮喘的临床疗效与安全性.方法:采用开放随机平行对照的方法,将患者随机分成两组:(1)试验组,吸入布地奈德400～800μg/d加上吸入沙丁胺醇200～400μg/d及溴化异丙托品42～84 μg/d;(2)对照组,单纯吸入布地奈德800～1 600μg/d.43例患者,疗程4周.结果:试验组患者平均晨间最大呼气流量(PEF)的改善和一秒钟用力呼气量(FEV1)及无症状天数的增加较对照组明显(P＜0.05).药物不良反应发生率试验组与对照组均是5%,两组间无差异(P＞0.05).结论:联合应用布地奈德和沙丁胺醇、溴化异丙托品,能有效改善肺功能,患者生活质量和控制哮喘症状,优于大剂量单纯吸入布地奈德.
- [1]R B, Dowling,M, Johnson,P J, Cole,etc.Effect of fluticasone propionate and salmeterol on Pseudomonas aeruginosa infection of the respiratory mucosa in vitro.[J].1999,14(2).
- [2]R A, Pauwels,C G, L?fdahl,D S, Postma,etc.Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group.[J].1997,337(20).
- [3].支气管哮喘防治指南（支气管哮喘的定义、诊断、治疗、疗效判断标准及教育和管理方案）[J].1997,(5).
- [4]R B, Dowling,C F, Rayner,A, Rutman,etc.Effect of salmeterol on Pseudomonas aeruginosa infection of respiratory mucosa.[J].1997,155(1).