Abstract： Objective To systematically integrate the caregiving experiences and needs of parents of adolescents with self-mutilation,and to provide references for appropriate caregiving interventions by immediate caregivers.Methods Chinese and English databases including CNKI,WanFang,VIP,CBM,PubMed,Web of Science,The Cochrane Library,Embase and CINAHL,as well as the grey literature repositories Grey Literature Sources,Google Scholar,GreyNet,Conference Proceedings were conducted from the inception of the repositories to January 31st 2024 to identify qualitative researches on the experiences and needs of parental caregiving for adolescents with self-mutilation.The literatures were evaluated through JBI quality assessment criteria,and the findings were analysed through a meta-synthesis approach.Results A total of 13 articles were included,and 34 findings were distilled and pooled into 9 new categories,which were summarized into 3 integrated findings:(1)affective changes in the process of discovery and understanding;(2)the impact of inadequate knowledge of the illness;(3)help-seeking and the consequences.Conclusion Parents of adolescents with self-mutilation experience multiple emotional changes and need to improve their understanding of the disease,actively seek help from multiple sources,and need to optimise healthcare services to alleviate physical and psychological stresses for patients and their parents.