Abstract： Objective To analyze the predictive value of miR-139-5p level in cerebrospinal fluid for postoperative recur-rence of glioma patients.Methods 55 patients with glioma were included in the study,and 20 patients with craniocerebral injury were used as the control group.2 weeks after operation,lumbar puncture was performed to collect cerebrospinal fluid samples,and the level of miR-139-5p in cerebrospinal fluid was detected by PCR.Patients with glioma were followed up for 6 months after oper-ation and divided into recurrence group and non-recurrence group according to the recurrence situation.Results The relative ex-pression of miR-139-5p in cerebrospinal fluid of glioma patients was(0.76 0.20),which was significantly lower than that of the control group(1.00 0.16).(P＜0.001).According to the follow-up results,patients with glioma were divided into recurrent group(n=10)and non-recurrent group(n=45).There was no significant difference in average age,gender distribution and tumor location between the 2 groups(P＞0.05).There were significant differences in tumor diameter,WHO staging,complete resection and the level of miR-139-5p between the 2 groups(P＜0.05).Patients with glioma with large tumor diameter,late WHO staging,incomplete resection of the lesion and low level of miR-139-5p are more likely to have postoperative recurrence than patients with small tumor diameter,early WHO staging,complete resection of the lesion and high level of miR-139-5p.The level of MiR-139-5p was significantly correlated with tumor diameter and WHO staging.ROC curve analysis showed that the level of miR-139-5p in ce-rebrospinal fluid had high predictive value for postoperative recurrence of glioma patients,and its area under the curve(AUC)for predicting postoperative recurrence was 0.898,and 95％CI was 0.8039～0.9916.Conclusion The level of miR-139-5p in cere-brospinal fluid of patients with glioma may affect the prognosis of patients by regulating the progression of glioma.The level of miR-139-5p in cerebrospinal fluid has certain predictive value for postoperative recurrence.