Abstract： Objective To analyze the prognostic factors of type 2 diabetes patients with breast cancer.Methods 80 pa-tients with type 2 diabetes mellitus and breast cancer were selected and all received radical mastectomy.They were followed up for 2 years.They were divided into poor prognosis group(with recurrence and metastasis)and good prognosis group(without recur-rence and metastasis)according to whether there was recurrence and metastasis.The related factors affecting the prognosis of type 2 diabetes mellitus patients with breast cancer were analyzed.Results Among 80 cases of breast cancer,22 cases had recurrence and metastasis,and the recurrence rate was 27.50％(22/80);Logistic regression analysis showed that late TNM stage,positive ER expression,2hPG＞10.0 mmol/L,HbA1C＞9％may be the prognostic factors of type 2 diabetes patients with breast cancer(P＜0.05).Conclusion Late TNM stage,positive ER expression,2hPG＞10.0 mmol/L,HbA1C＞9％may be the prognostic factors of type 2 diabetes patients with breast cancer.