Abstract： Objective To investigate the efficacy of multiport laparoscopic surgery for the treatment of patients with stageⅠ to Ⅲ ovarian cancer and its effect on peripheral blood T lymphocytes and postoperative complications.Methods 86 patients with stage Ⅰ～Ⅲ ovarian cancer who underwent surgical treatment were selected as study subjects and grouped according to the treatment protocols,of which 46 patients who underwent open surgery were the control group and 40 patients who underwent multi-hole laparoscopic surgery were the observation group.Perioperative indicators,survival quality score,peripheral blood T-lympho-cyte level and the occurrence of postoperative complications were used as observational indicators to evaluate the 2 treatment plans.Results There was no significant difference between the indicators of the 2 groups before treatment(P＞0.05).There was no significant difference in the operation time between the 2 groups(P＞0.05);After treatment,compared with the control group,the number of lymph node clearance,quality of survival score,CD3+,CD4+,and CD4+/CD8+levels in the observation group were significantly higher(P＜0.05);intraoperative hemorrhage,time to first gas evacuation,time to recovery of gastrointestinal function,CD8+level,and the total incidence of postoperative complications were significantly lower(P＜0.05).Conclusion Porous laparoscopic surgery for ovarian cancer patients can effectively improve the perioperative indicators and the level of periph-eral blood T lymphocytes,reduce postoperative complications,significantly improve the quality of life of patients,and has high clinical application value.