Abstract： Objective To evaluate the efficacy of laparoscopic-assisted minimally invasive nephron-sparing surgery in treating renal cancer patients and identify postoperative recurrence risk factors.Methods A total of 89 renal cancer patients were selected and divided into 2 groups based on the surgical approach.In the study group,40 patients underwent laparoscopic-assisted minimally invasive nephron-sparing surgery,while in the control group,49 patients underwent traditional laparoscopic radical ne-phrectomy.The clinical outcomes of the 2 groups were compared.Followed up for 2 years,postoperative recurrence and influence factors were analyzed.Results The study group showed better intraoperative blood loss,postoperative drainage,and other indica-tors compared to the control group,but the duration of surgery was longer in the study group(P＜0.05).There were no significant differences in preoperative renal function indicators between the 2 groups(P＞0.05),but postoperative renal function indicators improved in both groups compared to preoperative levels,with better results in the study group(P＜0.05).The incidence of com-plications in the study group(7.5％)was significantly lower than that in the control group(24.4％)(P＜0.05);age ≥65 years,hematuria,smoking,and lymph node metastasis were identified as risk factors for postoperative recurrence in renal cancer patients(P＜0.05).Conclusion Laparoscopic-assisted minimally invasive nephron-sparing surgery demonstrates superior efficacy in treating renal cancer patients,significantly improves renal function,reduces the incidence of postoperative complications,but has no impact on postoperative recurrence in renal cancer,thus warranting clinical application.