Abstract： Objective To compare the clinical effects of transabdominal and extraperitoneal laparoscopic radical surgery in patients with prostate cancer.Methods A retrospective analysis was conducted to collect the clinical data of 140 patients with prostate cancer who underwent laparoscopic radical surgery.They were divided into 2 groups according to the different surgical methods:the transabdominal group(n=70)and the extraperitoneal group(n=70).All patients were followed up for 6 months af-ter surgery.A baseline data questionnaire was designed by the researcher to collect detailed patient information and perioperative indicators(intraoperative blood loss,surgical duration,intestinal function recovery time,and postoperative catheter removal time).Urinary control rate and maximum urinary flow rate were also collected before and 6 months after surgery in both groups,and com-plications within 6 months after surgery were statistically analyzed.Results The amount of intraoperative bleeding,the recovery time of intestinal function,and the removal time of urinary catheter in the extraperitoneal group were lower than those in the transabdominal group,while the operation time was longer in the transabdominal group,with a statistical significant difference(P＜0.05).There was no statistical significant difference in preoperative urinary control rate and maximum urinary flow rate be-tween the 2 groups(P＞0.05).At 6 months after surgery,the urinary control rate and maximum urinary flow rate in the extraper-itoneal group were higher than those in the transabdominal group,with a statistical significant difference(P＜0.05).The inci-dence of complications within 6 months after surgery in the 2 groups was lower in the extraperitoneal group than in the transab-dominal group,with a statistical significant difference(P＜0.05).Conclusion Compared with transabdominal approach,extrap-eritoneal laparoscopic radical surgery can effectively shorten the recovery time of intestinal function and postoperative catheter re-moval time in patients with prostate cancer,reduce intraoperative bleeding,enhance postoperative urinary control ability,and have a lower incidence of complications.However,the surgical time is longer,and it is necessary to select an appropriate approach based on the patient's clinical situation.