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吉西他滨在膀胱癌中应用进展
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- Author:
- No author available
- Journal Title:
- Tianjin Pharmacy
- Issue:
- 2
- DOI:
- 10.3969/j.issn.1006-5687.2024.02.017
- Key Word:
- 膀胱癌;吉西他滨;预后;复发;灌注
Abstract： 膀胱癌是男性泌尿生殖系统中比较常见的恶性肿瘤之一,由于其治疗后易复发,患者的 5 年生存率较低.吉西他滨由于其脂溶性较高,易于渗入肿瘤细胞内,在肿瘤细胞内能快速达到最大有效药物浓度而发挥较强的抗肿瘤作用,因此临床将吉西他滨作为多种肿瘤治疗的基础用药.吉西他滨在膀胱癌的治疗中也有广泛的应用,本文通过检索近 5 年关于吉西他滨在治疗膀胱癌中的作用机制以及临床中的应用,总结和分析了常见灌注方式、灌注过程中的护理、灌注疗程、灌注周期、给药系统,并就其并发症处理和治疗、吉西他滨应用的优点和毒副作用等相关内容进行阐述,同时比较了吉西他滨与卡介苗、呲柔比星、表柔比星和丝裂霉素之间的不同,为吉西他滨在今后临床中的应用提供参考.
- [1]张文圣,陶韬,李勋钢,等.吉西他滨在非肌层浸润性膀胱癌术后行膀胱灌注患者中的应用效果[J].2021,(30).
- [2]兰东,黄国华,蓝建华,等.吉西他滨与吡柔比星对非肌层浸润性膀胱癌切除术后膀胱灌注不良反应与复发的差异性研究[J].2021,(10).
- [3]高翔,张大坤,马江伟,等.手术联合吉西他滨或吡柔比星膀胱灌注治疗老年膀胱癌的效果[J].2020,(1).
- [4]Azuma,H.,Inamoto,T.,Takahara,K.,etc.A great option for elderly patients with locally invasive bladder cancer, BOAI-CDDP-radiation (OMC regimen)[J].2013,43(4).
- [5]Steinberg, Ryan L.,Thomas, Lewis J.,Brooks, Nathan,etc.Multi-Institution Evaluation of Sequential Gemcitabine and Docetaxel as Rescue Therapy for Nonmuscle Invasive Bladder Cancer[J].2020,203(5).
- [6]Birtle, Alison,Johnson, Mark,Chester, John,etc.Adjuvant chemotherapy in upper tract urothelial carcinoma (the POUT trial): a phase 3, open-label, randomised controlled trial[J].2020,395(10232).
- [7]Coen, John J.,Zhang, Peixin,Saylor, Philip J.,etc.Bladder Preservation With Twice-a-Day Radiation Plus Fluorouracil/Cisplatin or Once Daily Radiation Plus Gemcitabine for Muscle-Invasive Bladder Cancer: NRG/RTOG 0712A Randomized Phase II Trial[J].2019,37(1).