Abstract： Objective To analyze the effect of voglibose combined with sitagliptin on glucose and lipid metabolism and insulin resistance in patients with type 2 diabetes mellitus(T2DM).Methods A total of 108 patients with T2DM admitted to Jian'ou Municipal Hospital from August 2022 to August 2023 were selected as the research objects.They were divided into control group and observation group by random envelope method,with 54 cases in each group.The control group was treated with single voglibose,and the observation group was treated with voglibose and sitagliptin.The clinical efficacy,glucose and lipid metabolism indexes,islet function indexes and inflammatory factor levels were compared between the two groups.Results The total effective rate of the observation group was 94.44%,which was higher than 81.48%of the control group,and the difference was statistically significant(χ2=7.930,P=0.005).After treatment,the fasting plasma glucose,2-hour postprandial plasma glucose,triglyceride and low density lipoprotein cholesterol in the two groups were lower than those before treatment,and the levels of each index in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the islet function indexes of the two groups were lower than before treatment,and the observation group were lower than the control group,the differences were statistically significant(all P<0.05).After treatment,the levels of interleukin-6 and tumor necrosis factor-α in the two groups were lower than those before treatment,and observa-tion group were lower than those in the control group,the differences were statistically significant(all P<0.05).Conclusion The combination regimen of voglibose and sitagliptin is effective in T2DM treatment,and has a signifi-cant effect on glucose and lipid metabolism and insulin resistance.