Abstract： Objective To explore the effect of dapagliflozin combined with linagliptin in the treatment of type 2 diabe-tes mellitus.Methods A total of 90 patients with type 2 diabetes mellitus treated in Yixing Sixth People's Hospital from January 2020 to January 2024 were selected as the study objects and divided into observation group and control group with 45 cases in each group by blind touch double-color ball method.The control group was treated with lina-gliptin,and the observation group was treated with dapagliflozin on the basis treatment of the control group.Blood glu-cose level,islet function and the occurrence of adverse reactions were compared between the two groups.Results Af-ter treatment,all blood glucose levels in the observation group were lower than those in the control group,and the dif-ferences were statistically significant(all P<0.05).After treatment,fasting insulin,islet cell function index and insulin resistance index in observation group were better than those in control group,and the differences were statistically sig-nificant(all P<0.05).There was no statistical significance in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion Dapagliflozin combined with linagliptin can improve blood glucose level and islet func-tion in patients with type 2 diabetes mellitus with good safety.