Abstract： Objective To explore the effect of Gegen Qinlian decoction on blood glucose control in diabetes mellitus and its influence on islet function and traditional Chinese medicine symptom score.Methods A total of 102 patients with diabetes who visited the rehabilitation Center for disabled Persons in Jilin Province from January 2022 to January 2024 were selected as the study objects and divided into the control group(basic sugar control treatment program)and the study group(the treatment program of based on the control group added Gegen Qinlian Decoction)by random num-ber table method,with 51 cases each.The improvement of blood glucose control,islet function and symptom scores were compared between the two groups.Results After 2 months of treatment,the levels of blood glucose and islet func-tion in the study group were lower than those in the control group,and the differences were statistically significant(both P<0.05).After 2 months of treatment,the scores of traditional Chinese medicine syndromes such as excessive eating and hunger,dry mouth and excessive drinking,fatigue and weakness,and urination frequency in the observa-tion group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion The diabetic patients received the basic glucose control program and Gegen Qinlian decoction combined treatment,the glucose control effect was better,and the islet function and traditional Chinese medicine symptom score were significantly improved.