Abstract： Objective To investigate the effect of early insulin intensive therapy after laparoscopic cholecystectomy in patients with type 2 diabetes mellitus(T2DM)complicated with biliary calculus.Methods Clinical data of 110 T2DM patients with biliary calculus who received laparoscopic cholecystectomy in Quanzhou First Hospital from August 2023 to February 2024 were retrospectively selected,and divided into control group(n=55,oral hypoglycemic agents)and observation group(n=55,early insulin intensive treatment was added to the treatment on the basis of of control group)according to different hypoglycemic methods.The adverse reactions,blood glucose level and clinical efficacy of the two groups were compared.Results There was no significant difference in the incidence of adverse reactions be-tween groups(P>0.05).After 4 weeks of treatment,the blood glucose levels in the observation group were lower than the control group,and the differences were statistically significant(all P<0.05).The clinical efficacy of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion After laparoscopic cholecystectomy for T2DM patients with biliary calculus,early intensive insulin therapy was selected,and no significant increase in adverse reactions was observed,abnormal glucose metabolism was effectively corrected,and clinical efficacy was improved.