Abstract： Objective To evaluate the effect of high quality nursing on elderly patients with diabetic nephropathy(DN)hemodialysis(HD)and its impact on their quality of life.Methods Sixty elderly patients with HD accepted DN admitted to Hanchuan Second People's Hospital from September 2020 to September 2023 were selected as the study objects,and they were divided into control group(30 cases,routine nursing)and observation group(30 cases,high quality nursing)according to random number table method.Self-rating Depression Scale(SDS)and Self-rating Anxi-ety Scale(SDS)scores,Comprehensive Quality of Life Assessment Questionnaire-74(GQOL-74)scores,nursing satis-faction,blood glucose level of two groups were compared.Results After nursing,SDS score,SAS score and blood glu-cose level in observation group were lower than control group,GQOL-74 score and nursing satisfaction level were higher than control group,and the differences were statistically significant(all P<0.05).Conclusion The implementa-tion of high quality nursing during HD in elderly patients with DN can alleviate anxiety and depression,improve blood glucose control effect,improve quality of life,and build harmonious nurse-patient relationship.