Abstract： Objective:To compare the clinical efficacy of oxycodone and sufentanil combined with propofol for hysteroscopic resection of endometrial polyps and select the relatively optimal dosage.Methods:A total of 120 patients undergoing hysteroscopic resection of endometrial polyps were randomly divided into three groups: Group Q1 (oxycodone 0.07 mg/kg) , Group Q2 (oxycodone 0.1 mg/kg) , and Group S (sufentanil 0.1 μg/kg) , with 40 cases in each group. All groups received intravenous injection of propofol at 2.0 mg/kg, and intraoperative changes in vital signs, propofol consumption, and surgical operation time were recorded. The VAS pain scores, Ramsay sedation scores, and adverse reactions during the recovery period were recorded for the three groups.Results:Group S had more episodes of respiratory depression compared to Group Q1 and Group Q2. There was no statistically significant difference in VAS scores during the recovery period among the three groups, and the difference in VAS scores between the three groups was less than 1 ( P>0.05) . Regarding Ramsay sedation scores, Group Q2 had higher scores than Group Q1 and Group S at the time of the patients wake up, while there was no significant difference between Group Q1 and Group S ( P>0.05) . Regarding adverse reactions, there was no statistically significant difference among the three groups postoperatively, and no adverse reactions occurred in any of the three groups. Conclusions:Compared with sufentanil in combination with propofol, oxycodone had fewer episodes of respiratory depression during endometrial polypectomy, and its anesthetic and analgesic effects during surgery were comparable to those of sufentanil in combination with propofol; oxycodone injection at a dose of 0.07 mg/kg is more suitable for hysteroscopic resection of endometrial polyps than 0.1 mg/kg oxycodone injection.