Abstract： Objective To investigate the effect of conservative treatment and endovascular treatment in patients with symptomatic isolated superior mesenteric artery dissection(ISMAD).Method The results of conservative treatment and endovascular treatment of ISMAD patients were searched from Web of Science,PubMed,CNKI and Wanfang database from the establishment of the database to October 1,2022.Meta-analysis was performed using RevMan 5.3 statistical software.Result A total of 11 literatures were included,with 664 cases of ISMAD.The results of Meta-analysis showed that the treatment effectiveness and long-term dissection remodeling rate of patients in the endovascular treatment group were significantly higher than those in the conservative treatment group,the differences were statistically significant(P<0.01).There was no significant difference in the recurrence rate of abdominal pain between two groups(P>0.05).Conclusion The effective rate and sandwich remodeling rate of intracavitary treatment for ISMAD patients are higher than those of conservative treatment,and there is no difference in the incidence of recurrent abdominal pain between the two methods.Therefore,intracavitary treatment for ISMAD is worthy of further promotion and application in clinical practice.