Abstract： Neuroblastoma (NB) is the most common extracranial solid tumor in children. Early NB has a decent prognosis with spontaneous regression or surgical resection alone. However, despite intensive treatments, 5-year survival rate of children with advanced NB has remained under 40% and half of them have a poor prognosis. As small extracellular vesicles secreted by a variety of cells, exosomes are rich in lipids, proteins and nucleic acids. Playing an important role in promoting the occurrence and development of NB, exosomes also participate in tumor metastasis and immune escape. This review summarized the latest researches of exosomes in neuroblastoma to provide references for clinical practices.