Abstract： AIM To study the pertinence of uric acid(UA)and neutrophil to lymphocyte ratio(NLR)in nonvalvular atrial fibrillation(NVAF)patients with carotid atherosclerosis(CAS).METHODS A total of 98 NVAF patients admitted to our department from February 2018 to August 2020 were selected.According to the results of carotid ultrasound,they were divided into sclerotic group(n=56)and non-sclerotic group(n=42).Another 40 patients with sinus rhythm and no history of atrial fibrillation were selected as control group.After 2 years of follow-up,cardiovascular events were recorded.The levels of UA,NLR,left ventricular mass index(LVMI),and incidence of cardiovascular events were compared in the three groups.To analyze the pertinence of UA,NLR and LVMI and the risk factors of cardiovascular events in NVAF with CAS.RESULTS The UA,NLR levels,and LVMI values in the sclerotic group were higher than those in the non sclerotic group and the control group(all P<0.01),while the UA,NLR levels,and LVMI values in the non sclerotic group were higher than those in the control group(all P<0.01).Pearson analysis showed a positive correlation between UA,NLR,and LVMI(r=0.438,r=0.379,P<0.01).The incidence of cardiovascular events in the sclerosis group was higher than that in the non sclerosis group(P<0.05)and the control group(P<0.01),while the incidence of cardiovascular events in the non sclerosis group was higher than that in the control group(P<0.05).Multivariate logistic regression analysis showed that CHA2DS2-VASc score,UA,NLR,and left atrial diameter(LAD)were independent risk factors for cardiovascular events in NVAF combined with CAS.CONCLUSION The increased levels of UA and NLR in NVAF patients with CAS are associated with myocardial remodeling and the incidence of cardiovascular events,which may provide a basis for clinical treatment.