Abstract： Objective To observe the clinical effect of compound dantong tablets combined with laparoscopic surgery in the treatment of cholelithiasis and its impact on gallbladder function and inflammatory factors.Methods 82 patients with gallstones admitted to Guangfeng District People's Hospital from March 2020 to March 2023 were randomly divided into a study group and a control group using a random number table method,41 cases each.Both groups underwent laparoscopic surgery.On this basis,the control group(41 cases)received postoperative routine treatment,while the study group(41 cases)received compound dantong tablets for treatment.The clinical efficacy of the two groups was compared.Results The total effective rate of treatment and gallbladder contraction function in the study group were higher than those in the control group,and the levels of procalcitonin(PCT),C-reactive protein(CRP),white blood cell count(WBC),gallbladder wall thickness and volume,postoperative complication rate were lower than those in the control group.The first exhaust time,hospitalization time,and bowel sound recovery time in the study group were shorter than those in the control group(P<0.05).Conclusion The combination of compound dantong tablets and laparoscopic surgery has a good effect on the treatment of gallstones,which can effectively correct gallbladder dysfunction,alleviate inflammatory stimulation,improve clinical symptoms,and have high treatment safety and practicality.