Abstract： Objective To study the effects of narrow-spectrum UVB,olopatadine combined with mometasone furoate on inflammation levels and neurotrophic factors in patients with localized neurodermatitis.Methods A total of 89 patients with localized neurodermatitis were randomly assigned from September 2021 to September 2023 in Zhoukou Hospital of Traditional Chinese Medicine.44 patients in the control group were given olopatadine combined with mometasone furoate,and 45 patients in the observation group were combined with narrow-spectrum UVB treatment on the basis of the control group.The clinical efficacy,levels of inflammation,levels of neurotrophin and adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group(P<0.05).After treatment,the levels of tumor necrosis factor-α in observation group were lower than those in control group,and the levels of interferon-γ and interleukin-2 were higher than those in control group(P<0.05);the levels of brain-derived neurotrophic factor and glial brain-derived neurotrophic factor in observation group were higher than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Narrow-spectrum UVB and olopatadine combined with mometasone furoate can effectively reduce the level of inflammation in patients with localized neurodermatitis,improve the level of neurotrophic factors,accelerate skin repair,and have high safety.