Abstract： Objective To investigate the therapeutic effect of tamsulosin combined with ureteroscopic holmium laser lithotripsy(UHLL)in patients with ureteral calculi.Methods 86 patients with ureteral calculi admitted to Wannian County Traditional Chinese Medicine Hospital from December 2021 to October 2023 were selected and randomly divided into two groups,43 cases in each group.The control group was treated with UHLL,and the observation group were treated with tamsulosin combined with UHLL.The stone free rate,incidence of urinary tract infection,renal function indicators,clinical symptom scores,and quality of life were compared between the two groups.Results The stone free rate of the observation group was higher than the control group;the incidence of urinary tract infection was lower than in the control group;the blood urea nitrogen,serum creatinine,abdominal colic score,urinary frequency,urgency score,hematuria score,nausea and vomiting scorein the observation group were lower than those in the control group;the psychological score,mental score,environmental score,physiological score,social relationship score,independence score,and general health and quality of life score in the WHOQOL-100 were higher than those in the control group(P<0.05).Conclusion Tamsulosin combined with UHLL can enhance the effect of stone removal,reduce urinary tract infection,promote the recovery of postoperative symptoms,and improve the quality of life.