Abstract： Objective:To study the effect of smart phone simplified augmented reality(AR) positioning puncture combined with nerve growth factor (NGF) precision drug delivery technology on the outcome of hypertensive supratentorial cerebral hemorrhage (SHICH) patients.Methods:A retrospective study was performed on 86 patients with SHICH admitted to Tangshan Hongci Hospital from February 2020 to January 2023. According to different treatment strategies, they were divided into puncture group and puncture + NGF group, each group with 43 cases. In both groups, the same group of doctors performed minimally invasive hematoma removal by smart phone simplified AR positioning puncture. The puncture +NGF group was additionally treated with NGF 30 μg through the nasal cavity once a day for 2 weeks. After treatment, the therapeutic effect was compared between the two groups; the cerebral edema volume, National Institutes of Health Stroke Scale (NIHSS) score, hematoma volume, Modified Barthel Index(MBI) score, S100B protein (S100B), neuron-specific enolase (NSE), matrix metalloproteinase-9 (MMP-9), myelin basic protein (MBP), aquaporin (AQP)-1, AQP-4, high mobility group protein B1 (HMGB1), C-reactive protein (CRP) before and after treatment were compared between the two groups; the Glasgow Outcome Scale (GOS) score and complications were compared between two groups.Results:The total effective rate in the puncture + NGF group was higher than that in the puncture group: 95.35%(41/43) vs. 81.40%(35/43), there was statistical difference ( χ2 = 4.07, P<0.05). After treatment for 3 d and 7 d, the brain edema volume, hematoma volume, NIHSS score in the puncture +NGF group were lower than those in the puncture group, while the MBI score was higher than that in the puncture group, there were statistical differences ( P<0.05). After treatment for 3 d and 7 d, the MMP-9, S100B, MBP, NSE, AQP-1, AQP-4, HMGB1 and CRP in the puncture +NGF group were lower than those in the puncture group, there were statistical differences( P<0.05). After treatment, the complication rate between the two groups had no statistical differences ( P>0.05). The GOS scores at 28 d of the two groups had statistical difference ( P<0.05). Conclusions:Smart phone simplified AR positioning puncture combined with NGF precision drug delivery technology can improve the prognosis of SHICH patients, improve the neurological function deficits, and enhance the daily activities.