Abstract： OBJECTIVE To understand the spatial pattern and change of human resources in provincial centers for Disease Control and Prevention(CDC)in Sichuan Province in the past ten years,explore the factors affecting the spatio-temporal flow of health personnel in disease control institutions,and provide reference for the optimal allocation of human resources in disease control institutions.METHODS Spatial autocorrelation and LISA test were used to analyze the spatial distribution and development trend of health workforce in Sichuan CDC,and the Spatial Dubin Model was used to explore the influencing factors.RESULTS The allocation of health personnel for disease control institutions in Sichuan Province showed an increasing trend from 2010 to 2020.The global Moran's I showed that the gap in the allocation of health personnel for disease control institutions in all cities showed a narrowing trend,and LISA results showed that the human resources in Ganzi Prefecture,Ya'an City,Suining City and northeast Sichuan region had local spatial autocorrelation.The results of Spatial Dubin Model showed that the regional gross domestic product(GDP)and resident population were important factors affecting the manpower allocation of CDC.CONCLUSION The allocation of health personnel in Sichuan CDC has been improved,but the spatial distribution is still unbalanced.It is suggested that health departments should comprehensively consider the factors such as service population and geographical distribution,and formulate reasonable human resource allocation standards for disease control institutions in different regions.At the same time,all regions should improve the performance incentive mechanism according to the urban development level,financial input,serving population,etc.,increase the talent introduction according to local needs,and further optimize the allocation of health personnel in CDC.