Abstract： In recent years,there has been a gradual increase in human infections caused by Mycobacterium perfringens.Hand infection caused by marine organism stings is a special type of infection,and its onset is closely related to Mycobacterium infection.Human beings can become infected through contact with contaminated water sources,aquatic products,etc.The article reports a case of hand infection with Mycobacterium infection and the diagnosis and treatment process of traditional Chinese medicine,provid-ing reference for the treatment of Mycobacterium infection.