Abstract： Objective To analyze epidemiological characteristics of pertussis in Yunnan province from 2018 to 2022.Methods We obtained data on pertussis cases reported during 2018-2022 in Yunnan from the China Disease Control and Prevention Information System for analyses of incidence and distribution.Results A total of 1 386 pertussis cases were reported in Yunnan from 2018 to 2022,yielding an average annual reported incidence of 0.59 per 100 000 population.Annual incidence per 100 000 increased from 0.19(91 cases)in 2018 to 1.29(605 cases)in 2022.Annual average incidences per 100 000 for 0-4-,5-9-,10-14-,and ≥15-year-olds were 8.03(1 143 cases),1.36(200 cases),0.17(27 cases),and 0.01(16 cases),respectively,with 32.98(917 cases,66.16％)among infants.Among the 1 056 cases with pertussis vaccination records,cases who had received 0,1,2,3,and 4 doses of pertussis-containing vaccine accounted for 41.57％,16.48％,4.64％,9.38％,and 27.94％.Laboratory-confirmed cases accounted for 65.08％(902 cases)of all cases,ranging from 20.88％(19 cases)in 2018 to 71.57％(433 cases)in 2022.Conclusions The incidence of pertussis increased from 2018 to 2022 in Yunnan,with the highest rate among infants.We need to continue strengthening routine pertussis vaccination of age-eligible children and improving pertussis surveillance sensitivity and laboratory diagnostic capacity.