Abstract： Objective To compare the efficacy of single-port laparoscopic unilateral salpingectomy and adnexectomy(ovary+fallopian tube)via different approaches,and to explore the safety and feasibility of single-port single-handed laparoscopy without access platform.Methods A total of 94 patients who underwent unilateral salpingectomy and 78 patients who underwent unilateral adnexectomy in our hospital from August 2021 to November 2022 were selected and randomly divided into the single-port single-handed without access platform group,the single-port double-handed without access platform group,and the single-port with access platform group,respectively.The operation time,intraoperative blood loss,postoperative morbidity,postoperative anal exhaust time,postoperative hospitalization time,total hospitalization cost,incision length,postoperative pain visual analogue scale(VAS)score,surgical complications,postoperative body image scale(BIS),and cosmetic score(CS)of patients in the three groups were observed and compared.Results There was no statistically significant difference in operative time,intraoperative blood loss,postoperative morbidity,postoperative anal exhaust time,postoperative hospitalization time,and surgical complications among the three groups(P>0.05).There were statistically significant differences in total hospitalization cost,incision length,postoperative VAS score,postoperative BIS score,and postoperative CS among the three groups(P<0.05).Conclusion Single-port single-handed laparoscopy salpingectomy and adnexectomy without access platform is a safe and feasible surgical method,which has the advantages of smaller incision,less hospitalization cost,and higher incision satisfaction than single-port surgery with access platform and single-port double-handed laparoscopic surgery without access platform.