Abstract： Objective:To explore the risk factor analysis and diagnostic efficacy prediction of acute kidney injury(AKI)combined with recurrent pancreatitis(ARP).Methods:This study was a retrospective case-control study, a total of 100 ARP patients admitted to the Emergency Medicine department of Xiamen University Xiang'an Hospital from April 2019 to December 2023, including 51 males and 49 females, aged(49.65±5.42)years old, ranging from 36 and 69 years old.The patients were divided into AKI group( n=30)and non-AKI group( n=70)according to whether they were combined with AKI or not.Independent risk factors affecting the occurrence of AKI in ARP were analyzed using univariate and multivariate logistic regression, diagnostic efficacy of each risk factor and combined index was analysed using the receiver operator characteristic(ROC)curve. Results:Patients in the non-AKI group had lower C-reactive protein[(37.91±5.37)mmol/L], calcitoninogen[(2.80±0.83)μg/L], blood urea nitrogen[(7.24±0.84)μmol/L], and acute physiology and chronic health evaluationⅡscore[10.1(8.9, 11.6)points] than those in the AKI group[(46.32±3.01)mmol/L, (4.62±0.93)μg/L, (9.08±1.28)μmol/L, and 18.9(17.8, 20.4)points], and the interval between AP episodes[11.0(8.8, 13.6)months] was higher than that in the AKI group[8.9(6.1, 11.3)months], acute pancreatitis grading status, systemic inflammatory response syndrome situation, abdominal septal compartment syndrome situation, and hypovolemia situation, assisted ventilation situation were better than that of the AKI group, and the difference was statistically significant( P<0.05).High C-reactive protein and high calcitoninogen were independent risk factors affecting the occurrence of AKI( OR=1.904, 95% CI: 1.406 to 2.577; OR=11.448, 95% CI: 4.265 to 30.731, P<0.05).C-reactive protein, calcitoninogen, blood urea nitrogen and their combined tests all had high diagnostic C-reactive protein, calcitonin, blood urea nitrogen and their combined test all had higher diagnostic efficacy for ARP combined AKI, and the combined test was better than C-reactive protein, calcitonin and blood urea nitrogen alone( P<0.05). Conclusions:High C-reactive protein and high calcitonin are independent risk factors affecting the occurrence of AKI, and C-reactive protein, calcitonin, blood urea nitrogen and their combination can have higher diagnostic efficacy for ARP combined AKI, and the combination test is better than C-reactive protein, calcitonin and blood urea nitrogen alone.