Abstract： Gut dysbiosis is closely associated with the development of Alzheimer's disease(AD).Accumulating evidence has revealed the specific changes of the gut microbial compositions and diversity in the whole spectrum of AD.However,the regulatory mechanisms of the gut microbiota on cognitive function remain unclear.Recently,with the rapid advances of neu-roimaging techniques,the combination of the gut microbiota and multi-modal neuroimaging techniques may provide an effective approach for substantially exploring the interactions of the"gut-brain axis".In this review,we aim to summarize the progress of radiomicrobiomics in AD.