Abstract： The treatment of bullous pemphigoid(BP)is mainly based on glucocorticoids at present.Dupi-lumab is a new drug for the treatment of BP,and its efficacy has been confirmed in many literatures at home and abroad.But glucocorticoid combined with dupilumab in treatment of verruca plana was no related reports.We report a case of BP with stable control and regression of generalized verruca plana after the treatment of glucocorticoid combined with dupilumab.The short-term regression of verruca plana in this case may be relat-ed to the regulation of immune function and the repair of skin barrier by dupilumab.