Abstract： Gardner-Diamond syndrome(GDS)is a rare disease characterized by spontaneous painful bruises,which is more common in females and often associated with mental illness.The etiology and mecha-nism of the disease are not clear,and and mental factors may play a key role.We report a case of GDS with postpartum depression,presented with painful bruises on the limbs,and was accompanied by transient coagu-lation factor abnormalities.After the treatment for depression for 1 month,ecchymosis and pain symptoms were relieved,and there was no recurrence after 4 years follow-up.