Abstract： Objective To investigate the interaction between HbA1c level and dyslipidemia on diabetic peripheral neuropathy(DPN).Methods A total of 110 patients with DPN who were hospitalized in the Department of Endocrinology of the Third Affiliated Hospital of Soochow University were selected as the DPN group,and 110 patients with T2DM who were treated in the Third Affiliated Hospital of Soochow University during the same period were selected as the T2DM group from July 2020 to July 2021.LASSO regression and Logistic regression analysis were used to evaluate the influencing factors for T2DM patients complicated with DPN.The interaction of high HbA1c and dyslipidemia on DPN was analyzed by additive interaction model,and the diagnostic value of high HbA1c,dyslipidemia and their interaction on DPN was analyzed by ROC curve.Results The age,smoking history,SBP,WC,TG and HbA1c were higher in DPN group than in T2DM group(P<0.05).LASSO and logistic regression analysis showed that age,smoking history,SBP,WC,TG,HDL-C and HbA1c were the influencing factors for DPN in T2DM patients.The results of qualitative and quantitative analysis showed that there was an interaction between high HbA1c and dyslipidemia in DPN risk in patients with T2DM.ROC curve analysis showed that the diagnostic value of high HbA1c and dyslipidemia combination was higher in DPN diagnosis than each parameter alone.Conclusions TG,HDL-C and HbA1c are the influencing factors for DPN in T2DM patients,and there is a synergistic interaction.High HbA1c and dyslipidemia increase the risk of DPN in T2DM patients.