Abstract： Objective To explore the correlation between continues glucose monitoring(CGM)parameters and nerve conduction velocity(NCV)in patients with diabetic peripheral neuropathy(DPN).Methods A total of 180 T2DM patients who visited our Endocrinology Department were enrolled in this study from June 2020 to June 2022 and divided into simple type 2 diabetes mellitus(T2DM)group(n=30)and a T2DM combined with DPN group(DPN,n=150)based on whether they had DPN.The DPN group was further divided into mild DPN subgroup(VPT 16～24 V,n=51),moderate DPN subgroup(VPT 25～39 V,n=67),and severe DPN subgroup(VPT≥40 V,n=32)according to the VPT.Results Compared with T2DM group,DM duration,SUA,TBIL,AST,TC,TG,LDL-C and GSP were increased in DPN group(P<0.05 or P<0.01).MAGE,LAGE,MBG,SDBG and FBG-CV in mild,moderate and severe subgroups of DPN increased in turn(P<0.01),while TIR,MNCV and SNCV decreased in turn(P<0.01).Hierarchical regression model analysis showed that MAGE,LAGE,MBG,FBG-CV were the influencing factors for MNCV and SNCV.Logistic regression analysis showed that MAGE,LAGE,MBG,FBG-CV,MNCV and SNCV were all influencing factors for DPN severity.Interaction analysis showed that MNCV,SNCV,MAGE,LAGE,MBG and FBG-CV all had additive and multiplying interactions on the severity of DPN.Conclusions MAGE,LAGE,MBG,FBG-CV,MNCV,and SNCV are factors that affect the severity of DPN,with additive and multiplicative interactions present.