Abstract： Objective:To investigate the efficacy of pulsed radiofrequency in the treatment of provoked versus central reorganization postherpetic neuralgia.Methods:A total of 190 patients with postherpetic neuralgia admitted to the pain department of the Affiliated Hospital of Southwest Medical University from January 2020 to March 2023 were screened in the study.A total of 90 cases were enrolled according to the inclusion and exclusion criteria,and divided into a central reorganization group(30 cases in the central reorganization group)and an irritant group(30 cases in the irritant group)based on the propensity score matching.All patients were received the treatment of ultrasound-guided pulsed radiofrequency of peripheral nerves.The NRS scores and PSQI scores of PHN patients in both groups were evaluated at the time of pretreatment and 1 week postoperatively and 1,3,and 6 months follow-up,and the efficacy was evaluated at 6 months postoperatively.Results:NRS and PSQI scores were lower in both groups of patients at all postoperative time points compared with preoperative(P<0.05).Compared with the central reorganization group,patients in the irritant group had lower NRS scores at 3 months postoperatively(P<0.05)whereas the difference in NRS scores between the two groups was not statistically significant at 1 week postoperatively,1 and 6 months postoperatively.At 6 months postoperatively,there was no statistically significant efficacy difference between the two groups.However,the effective rate of the central reorganization group was 93.3%,and the effective rate of the irritant group was 70.0%(P<0.05).Conclusion:Pulsed radiofrequency is effective in relieving pain in patients with postherpetic neuralgia,and there is no difference in mid-and long-term efficacy between the two groups.However,the central reorganization group was more efficient.