Abstract： Both the financial burden and quality of life of patients are greatly impacted by chronic pain.Exist-ing treatment modalities often fall short in adequately meeting the analgesic needs of patients.The biological genome has been increasingly well understood in recent years.In the meantime,the development of precise delivery systems provide effective techniques for gene therapy,which can target the delivery of anti-noceptive molecules or block pain transmission.Currently,many pain-related targets have been discovered,and these different targets can mediate different types of pain.This has generated fresh notions for gene therapy to treat chronic pain.Although there are many potential uses for the newly developed gene therapy,there are also many obstacles to overcome.This article primarily summarizes ion channel targets associated with gene therapy for chronic pain,offering suggestions for additional target exploration.