Abstract： We report five elderly patients with refractory bullous pemphigoid treated with dupuyuzumab.The average age was 78.2 years old,and they were complicated with various basic diseases.After a definite diagnosis,the skin lesions of bullous pemphigoid were controlled and the itching was obviously relieved after the regular treatment of duprizumab for 3-5 times,and the patients were followed up regularly.Duplex monoclonal antibody is a monoclonal antibody of human IgG4-4.By binding to the common chain of IL-4R and IL-13R-subunits,it blocks the IL-4/13 signaling pathway,thus interrupting the inflammatory pathway of BP.It can also reduce the secretion of IL-31 through its direct action on IL-4 and IL-13 and its action on eosinophils,thus reducing the signal transmission of peripheral itch sensory neurons.