Abstract： Objective To explore the effect of risk management model based on failure mode and effect analysis(FMEA)theory in patients with systemic lupus erythematosus.Methods Totally,116 patients with systemic lupus erythematosus were included in the study and grouped using a random number table.The control group implemented routine risk management,while the experimental group implemented risk management based on FMEA theory.Compare compliance,disease activity before and after management,symptom scores and total scores before and after management,and incidence of complications between two groups during the management period.Results The difference in compliance distribution between the two management periods was statistically significant(P＜0.05);The complete compliance rate during the management period of the experimental group was higher than that of the control group(P＜0.05);Compared with before management,the disease activity rate of both groups decreased after management,and the experimental group was lower than the control group(P＜0.05);Compared with before management,the symptom scores and total scores of both groups decreased after management,and the experimental group was lower than the control group(P＜0.05);The incidence of complications during the management period in the experimental group was lower than that in the control group(P＜0.05).Conclusion Risk management model based on FMEA theory can improve the compliance of patients with systemic lupus erythematosus,improve clinical symptoms,and reduce the risk of complications.