Abstract： [Purpose]To analyze the colorectal cancer screening results among high-risk population in Inner Mongolia from 2017 to 2021.[Methods]The compliance rate of colonoscopy screening was compared among populations with different demographic characteristics by x2 test.The factors related to compliance rate of colonoscopy screening were examined by the binary multivariate Lo-gistic regression model.The detection rate of colorectal cancer were analyzed by sex,age,and ethnic groups.[Results]A total of 41 002 cases of high risk for colorectal cancer were identified,accounting for 22.73％of all screening participants,among whom 9 572 underwent colonoscopy examinations with a compliance rate of 23.35％;pathological biopsy was completed in 3 438 cases with biopsy rate of 35.92％.Positive findings were detected in 973 cases(10.17％),including 41 cases of colorectal cancer(0.43％)and 932 cases of precancerous lesions(12.65％).Multivariate Logistic regression analysis showed that people with age＞45 years old(OR=0.258,0.235,0.164),living in Bayannur(OR=0.634),working in agricultural,industrial and commercial service sectors(OR=0.889)were less willing to undergo colonoscopy screening.People with junior high school edu-cation(OR=1.586),senior high school education(OR=1.698),university and above(OR=1.534)were more willing to be screened.Alcohol drinkers(OR=1.256),people with chronic colitis(OR=1.677),other diseases of lower digestive system(OR=1.367)and positive fecal occult blood test(OR=1.416)were more willing to undergo colonoscopy screening.[Conclusion]The compliance of colonoscopy in urban cancer screening areas in Inner Mongolia is low.The screening results suggest that the screening and prevention of colorectal cancer in men and the elderly should be strengthened.