Abstract： Wound healing is a complex process of biological integration in which the adverse conditions such as excessive inflammatory reactions,cell proliferation and migration disorders,and cellular secretion impairment can lead to refractory wounds.Characterized by complex etiology,protracted condition,and high morbidity and recurrence rate,refractory wounds severely impair patients'physical and mental health.In clinical practice,refractory wounds are primarily treated with surgical debridement and skin transplantation,but there still exist problems such as large surgical wounds,prolonged recovery time,and high recurrence rate.In recent years,owing to the multipotent differentiation,immunomodulatory,and paracrine functions of stem cells,cell-assisted lipotransfer(CAL)technique,which involves intra-body injection of a mixture of autologous adipose-derived stem cells(ADSCs)and granular fat for refractory wound repair,has demonstrated promising application prospects.It is of great significance in its clinical application to clarify the mechanism of effects of CAL technique in refractory wound repair.The authors reviewed the research progress in the mechanism of effects of CAL technique in repairing refractory wounds to provide references for the research and treatment of refractory wounds.