Abstract： Objective:To study the effect of hyperbaric oxygen comprehensive treatment on the clinical efficacy，cognition，anxiety，and depression of patients with spinal cord injury.Methods:A total of 100 patients with spinal cord injury who received treatment in Linyi Central Hospital from January 2019 to January 2022 were randomly divided into control group and observation group，with 50 cases in each. The control group received traditional rehabilitation treatment and psychological therapy，while the observation group received combined hyperbaric oxygen therapy on the basis of the treatments of the control group. The clinical efficacy，quality of life score，cognitive function，anxiety and depression levels of the two groups before and after treatment were compared.Results:The total effective rate of the observation group（98.00%）was significantly higher than that of the control group（84.00%），and the difference was statistically significant（ P<0.05）；after treatment，the TDL-QOLAS（75.73 ± 8.74）and MMSE（19.45 ± 2.62）scores of the observation group were significantly higher than those of the control group［（87.54 ± 7.65），（23.25 ± 3.45）］；while BAI（42.74 ± 4.26）and ICD-10（16.52 ± 3.54）scores were lower than those of the control group［（57.76 ± 5.54），（27.72 ± 4.58）］，and the differences were statistically significant（ P<0.05）. Conclusion:Postoperative rehabilitation combined with hyperbaric oxygen have obvious curative effects on patients with spinal cord injury and can effectively relieve patients’ cognitive dysfunction，anxiety，and depression.