Abstract： Objective:To explore the effect of multi-sensory training combined with music therapy on hyperbaric oxygen therapy on children with cerebral palsy（CP）.Methods:A total of 42 children with CP treated in Children’s Hospital of Shanxi from February 2019 to February 2022 were selected into observation group，and another 40 children with CP treated in the same department from January 2016 to January 2019 were selected into control group，all of whom received hyperbaric oxygen combined with music therapy for six courses. The observation group received multi-sensory training on the basis of the treatments of the control group. The language development level of the children before and after treatment was evaluated by symbol and indicative content relationship method，and the clinical efficacy and total developmental quotient before and after treatment were compared between the two groups.Results:The clinical efficacy of children in the observation group［92.86%（39/42）］was higher than that in the control group［77.50%（31/40）］，and the difference was statistically significant（ P<0.05）. With the progress of treatment，the total developmental quotient of the children in the two groups showed an increasing trend，and the total developmental quotient of children in the observation group was higher than that in the control group after four and six courses of treatment，with statistical significant differences（ P<0.05）. Conclusion:When hyperbaric oxygen is applied to treat children with CP，the clinical efficacy of the treatment combined with multi-sensory training and music therapy is higher than that of the treatment combined with music therapy alone，which can improve language development and total developmental quotient of children with CP.