Abstract： Objective:To provide references for the prevention and treatment of hyperuricemia (HUA) in aircrews by investigating the prevalence of HUA in aircrews and analyzing the correlation between HUA and other biochemical indicators.Methods:The physical examination data of male aircrews who participated in physical examination in Beidaihe Rehabilitation and Recuperation Center of PLA from 2020 to 2022 were retrospectively analyzed. According to the year, they were divided into 2020, 2021 and 2022 groups. According to the age, they were divided into 20-29, 30-39, 40-49 and 50-59 years groups. The prevalence of HUA among different years and age groups were compared and analyzed. The subjects were divided into HUA group and non-HUA group according to whether they had HUA. The differences of physical examination indexes were compared between 2 groups, and the potential effects of other biochemical indexes on HUA were analyzed by multivariate Logistic regression.Results:A total of 2 365 aircrews were enrolled. Eight hundred and sixty-six aircrews were diagnosed as HUA, accounting for 36.62%. The prevalence rate increased year by year, and the difference was statistically significant ( χ2=6.70, P=0.010). There was no significant difference in prevalence rate among different age groups ( P>0.05). There were significant differences in creatinine ( t=9.40, P<0.001), serum uric acid ( t=59.66, P<0.001), urea nitrogen ( t=4.60, P<0.001), direct bilirubin ( Z=3.40, P=0.001), alanine aminotransferase ( Z=7.59, P<0.001), low density lipoprotein cholesterol ( t=5.89, P<0.001), triglyceride ( Z=8.02, P<0.001) and total cholesterol ( t=6.79, P<0.001) between HUA group and non-HUA group. Multivariate Logistic regression analysis showed that increased alanine aminotransferase ( OR=1.014, P<0.001), urea nitrogen ( OR=1.091, P<0.001), creatinine ( OR=1.038, P<0.001), and triglyceride ( OR=1.164, P=0.001) level were the risk factors for HUA. Conclusions:The prevalence of HUA in aircrew is increasing year by year. Alanine aminotransferase, urea nitrogen, creatinine and triglyceride are the risk factors for HUA. It is suggested that attention should be paid to the increasing trend of HUA in aircrews year by year, to the impact of abnormal liver and kidney function on metabolism and blood lipid levels, and early intervention measures should be taken for related risk factors.