Abstract： Objective:To provide a basis for dealing with passengers′ health safety events by understanding the disease spectrum of passengers′ health safety events.Methods:Passengers who experienced health safety events in the cabin of an airline from 2021 to 2022 were select as the research objects, and the types and characteristics of diseases were analyzed.Results:A total of 1 226 health safety events among air passengers from 2021 to 2022, including 563 cases for man and 663 cases for woman, with a gender ratio of 0.85∶1, and the average age of all cases was (45.03±19.91) years old. The top 5 diseases were damage (30.67%), cardiovascular system disease (23.25%), digestive system disease (11.42%), respiratory disease (11.17%) and nervous system disease (10.03%). The luggage falling and burn caused injuries took high incidence in damage. Cardiovascular diseases mainly included angina pectoris and myocardial infarction. Digestive system diseases included symptoms such as abdominal discomfort, abdominal pain, diarrhea and vomiting caused by diet. Respiratory diseases mainly included asthma, bronchiectasis, lung tumor, and acute upper respiratory tract infections. Epilepsy ranked the first in nervous system diseases.Conclusions:Damage, cardiovascular system, digestive system, respiratory system, and nervous system diseases rank the top diseases in the disease spectrum of air passengers′ health safety events. Those provide the reference to passenger's safety management for making the countermeasure and emergency plan. The risk notification and reminder, as well as the publicity of traveling safety should be strengthened.