Abstract： Objective:To explore and predict the short-term efficacy of neuronavigation-guided treatment for basal ganglia hypertensive intracerebral hemorrhage (HICH).Methods:A retrospective analysis was conducted on the clinical data of 56 patients with basal ganglia HICH admitted to Neurosurgery Department of Liaoning Provincial People's Hospital from January 2020 to June 2021. According to different puncture positioning methods, they were divided into two groups. The control group (35 cases) received traditional localization puncture treatment, while the experimental group (21 cases) received neuronavigation-guided localization puncture treatment. The GCS score at 1 week after surgery, complications and the Barthel index (BI) score at 6 months after surgery between the two groups were compared. Multivariate Logistic regression were used to analyze the benefit factors of different surgical methods for basal ganglia HICH, and the R software was used to construct a nomogram risk prediction model and verify the effect.Results:There was no statistical difference in intra-pulmonary infections, and the incidence of stress ulcers between the two groups (P>0.05). The experimental group had a higher GCS score at 1 week after surgery than the control group, lower residual blood volume and hospitalization days than the control group, the longer surgical operation time than the control group, and the BI score at 6 months after treatment was better than that of the control group, with statistical significances (P<0.05). Multivariate Logistic regression analysis showed that postoperative residual blood volume and hospitalization days were independent benefit factors. The internal verification of the Bootstrap method showed that the calibration curve showed that the model was well calibrated.Conclusion:Surgical treatment of basal ganglia HICH assisted by neuronavigation can reduce postoperative intracerebral residual blood and hospitalization days, promote the recovery of long-term self-care ability after surgery, and provide a new therapeutic option for promoting the rehabilitation of cerebral hemorrhage patients and early return to society.