Abstract： Objective To explore the predictive value of growth differentiation factor-15(GDF-15)and alkaline phosphatase(ALP)levels on the degree of coronary artery disease in patients with coronary atherosclerotic heart disease(CHD).Methods A total of 140 patients hospitalized in the Department of Cardiovascular Medicine,Inner Mongolia People's Hospital from January 2021 to December 2023 were selected.According to the final diagnosis,they were divided into CHD with diabetes mellitus group(46 cases),CHD group(51 cases)and control group(43 cases of non CHD patients without obvious stenosis in coronary angiography).The levels of GDF-15,ALP,and Gensini score were compared,and the differences in the composition ratio of different ethnic among three groups of patients and the above indicators among different ethnic patients were compared.The relationship between GDF-15 and ALP levels and the risk of CHD,as well as their predictive value for the degree of coronary artery disease were analyzed.Results The GDF-15,ALP levels and Gensini score in CHD group and CHD with diabetes mellitus group were higher than those in control group,while those in CHD with diabetes mellitus group were higher than those in CHD group(all P＜0.05).There was no statistically significant difference in the proportion of different ethnicities among the three groups(P＞0.05).There was no statistically significant difference in GDF-15,ALP levels and Gensini score between Han and Mongolian patients(all P＞0.05).The results of Logistic regression analysis showed that the risk of CHD increased with an increase of the levels of GDF-15(odds ratio=2.356,95％confidence interval:1.608-3.451,P＜0.001)and ALP(odds ratio=1.117,95％confidence interval:1.019-1.225,P=0.019).The analysis of the receiver operating characteristic showed that,the area under the curve(AUC)for predicting the degree of coronary artery disease using GDF-15,ALP,and their combination were 0.929,0.796,and 0.939,respectively.The AUC predicted by the combination of GDF-15 and ALP was greater than that of a single indicator(both P＜0.05).Conclusions The expression levels of ALP and GDF-15 in patients with CHD increased and are related to diabetes mellitus and the degree of coronary artery disease.The combined detection of the two indexes has a good predictive value for the degree of coronary artery disease.