Abstract： Cerebral white matter injury is a significant contributor to enduring sensorimotor and cognitive impairments post stroke.Microglia are pivotal in modulating immune-inflammatory responses within the central nervous system and play a dual role in both exacerbating injury and facilitating repair in cases of ischaemic stroke-induced white matter injury.This highlights the potential efficacy of acupuncture as a therapeutic intervention target these mechanisms.Recently,the potential mechanism of acupuncture in improving the prognosis of white matter injury post ischemic stroke through the regulation of microglia has attracted much attention.Acupuncture mainly ameliorates the inflammatory milieu and facilitates myelin regeneration and repair by suppressing the TLR4 signaling pathway,reducing MMP-9 expression,and promoting the expression of ANXA1 and TERM2.