Abstract： With the aggravation of aging in China,the incidence and mortality of multiple myeloma(MM)are increasing year by year.Although anticancer drugs are constantly emerging,the treatment of MM is still facing severe challenges due to tumor metastasis and drug resistance.Clinical studies have shown that growth and differentiation factor 15(GDF15)is associated with a variety of MM serum markers,including β2-microglobulin(β2-MG).In addition,in vitro cell studies have confirmed that GDF15 maintains the self-renewing and proliferation of tumor cells by activating Akt/SOX2 and its downstream microRNA-143-3p/c-MET and Bmi-1/Bim.GDF15 is also involved in regulating MDR1 and Bax/Bcl-2 to promote MM drug resistance.Although GDF15 is found to promote MM metastasis,its mechanism of action remains to be elucidated.This review summarizes the role and mechanism of GDF15 in various physiological activities of MM,and the further study of GDF15 on MM resistance and metastasis is expected.